Risk factors for venous thromboembolism in glioma patients

Background: Ranking third in the cause of death structure, venous thromboembolism (VTE) is a frequent complication patients with central nervous system tumors.Objective: To assess incidence thrombosis and its risk factors glioma based on retrospective data.Methods: Our study included 186 from Neurosurgery Department Almazov National Medical Research Centre.Results: The VTE was 8% brain neoplasms. Comparative analysis 2 groups to identify predictors showed that probability increases leading patient immobilization: altered mental status (40% [n = 6] group vs 18% 30] non-VTE group, OR: 3.1 [95% СI: 0.8–10.6], P .080), neurological deficit (67% 50] 29% 10], 4.8 1.4–18.7], .007), bed rest for more than 3 days (33% 4%, 13.1 2.7–62.8], < .001). Based validation results, Caprini IMPROVEDD scores have high negative predictive values: 0.99 0.93–1.00] 0.97 0.93–0.99] (P .317). score has specificity 48.2% sensitivity 93.3% (AUC 78.98); threshold value high-risk detection 5.5 points. 82.5% 73.3% 81.1); 4.5 points.Conclusion: revealed patients, such as deficit, prolonged (more days), high-grade tumor. We demonstrated values determined their be validated further prospective study. Due risks hemorrhage tumors, personalized calculators should developed, providing features pathogenesis this group. Received 12 December 2022. Revised 7 April 2023. Accepted 31 May Funding: supported by Ministry Science Higher Education Russian Federation (No. 075-15-2022-301). Conflict interest: authors declare no conflict interest. Contribution authorsConception design: K.A. Pishchulov, M.A. SimakovaData collection analysis: S.I. ParkhomenkoStatistical V.L. LukinovDrafting article: Simakova, Lukinov, Parkhomenko, N.E. Voinov, S.S. Sklyar, O.M. MoiseevaCritical revision MoiseevaFinal approval version published: Moiseeva